Mark Richardson

King’s College London

Mark is the Vice Dean of the Division of Neuroscience at the Institute of Psychiatry, Psychology & Neuroscience, King’s College London. He is both a practicing neurologist, regularly holding epilepsy clinics at King’s College Hospital, as well as a research team leader, running a lab whose focus is on understanding the mechanisms of epilepsy using multi-modal brain imaging approaches.

Qualifications:

  • MA (Cambridge)
  • BM BCh (Oxford)
  • PhD (UCL)
  • FRCP

Core expertise:

  • MRI
  • EEG
  • TMS
  • Epilepsy

Profile links:

Publications and Posters:

  • Towgood K, Barker GJ, Caceres A, Crum WR, Elwes RDC, Costafreda SG, Mehta MA, Morris RG, von Oertzen TJ, Richardson MP. Bringing memory fMRI to the clinic: Comparison of seven memory fMRI protocols in Temporal Lobe Epilepsy. Human Brain Mapping, in press.
  • Mporas I, Tsirka V, Zacharaki EI, Koutroumanidis M, Richardson M, Megalooikonomou V. Seizure detection using EEG and ECG signals for computer-based monitoring, analysis and management of epileptic patients. Expert Systems with Applications, in press.
  • Keller SS, Richardson MP, O’Muircheartaigh J, Schoene-Bake JC, Elger C, Weber B. Morphometric MRI alterations and postoperative seizure control in refractory temporal lobe epilepsy. Human Brain Mapping, in press.
  • Chowdhury FA, Pawley AD, Ceronie B, Nashef L, Elwes RDC, Richardson MP. Motor evoked potential polyphasia: a novel endophenotype of Idiopathic Generalised Epilepsy. Neurology, in press.
  • Petkov G, Goodfellow M, Richardson M, Terry J. A critical role for network structure in seizure onset: a computational modelling approach. Frontiers in Neurology, in press.
  • Rey HG, Ison M, Pedreira C, Valentin A, Alarcon G, Selway R, Richardson MP, Quian Quiroga R. Single cell recordings in the human medial temporal lobe. J Anat, 2014 in press.
  • Chowdhury FA, O’Gorman RL, Nashef L, Elwes RD, Edden RA, Murdoch JB, Barker GJ, Richardson MP. Investigation of glutamine and GABA levels in patients with idiopathic generalized epilepsy using MEGAPRESS. J Magn Reson Imaging. 2014 in press.
  • Schmidt H, Petkov G, Richardson MP, Terry JR. Dynamics on networks: the role of local dynamics and global networks on the emergence of hypersynchronous neural activity. PLoS Comput Biol. 2014;10:e1003947.
  • Chowdhury FA, Woldman W, FitzGerald TH, Elwes RD, Nashef L, Terry JR, Richardson MP. Revealing a brain network endophenotype in families with Idiopathic Generalised Epilepsy. PLoS One. 2014 Oct 10;9(10):e110136.
  • Centeno M, Vollmar C, Stretton J, Symms MR, Thompson PJ, Richardson MP, O’Muircheartaigh J, Duncan JS, Koepp MJ. Structural changes in the temporal lobe and piriform cortex in frontal lobe epilepsy. Epilepsy Res 2014;108:978-81.
  • Chowdhury FA, Elwes RD, Koutroumanidis M, Morris RG, Nashef L, Richardson MP. Impaired cognitive function in IGE and unaffected family members: an epilepsy endophenotype. Epilepsia, 2014;55:835-40.
  • Brunnhuber F, Amin D, Nguyen Y, Goyal S, Richardson MP. Development, evaluation and implementation of video-EEG telemetry at home. Seizure, 2014 May;23:338-43.
  • Keller SS, O’Muircheartaigh J, Traynor C, Towgood K, Barker GJ, Richardson MP. Thalamotemporal impairment in temporal lobe epilepsy: A combined MRI analysis of structure, integrity and connectivity. Epilepsia, 2014;55:306-15.
  • Kralj-Hans I, Goldstein LH, Noble AJ, Landau S, Magill N, McCrone P, Baker G, Morgan M, Richardson M, Taylor S, Ridsdale L. Self-Management education for adults with poorly controlled epILEpsy (SMILE (UK)): a randomised controlled trial protocol. BMC Neurol. 2014 3;14:69.
  • Wandschneider B, Centeno M, Vollmar C, Stretton J, O’Muircheartaigh J, Thompson PJ, Kumari V, Symms M, Barker GJ, Duncan JS, Richardson MP, Koepp MJ. Risk-taking behavior in juvenile myoclonic epilepsy. Epilepsia. 2013;54:2158-65.
  • Fitzgerald TH, Valentin A, Selway R, Richardson MP. Cross-frequency coupling between the human thalamus and neocortex. Front Hum Neurosci. 2013;7:84.
  • Nicholas JM, Ridsdale L, Richardson MP, Grieve AP, Gulliford MC. Fracture risk with use of liver enzyme inducing antiepileptic drugs in people with active epilepsy: Cohort study using the General Practice Research Database. Seizure. 2013;22:37-42.
  • Valentín A, Nguyen HQ, Skupenova AM, Agirre-Arrizubieta Z, Jewell S, Mullatti N, Moran NF, Richardson MP, Selway RP, Alarcón G. Centromedian thalamic nuclei deep brain stimulation in refractory status epilepticus. Brain Stimul. 2012;5:594-8.
  • Bergin P, Sadleir L, Legros B, Mogal Z, Tripathi M, Dang N, Beretta S, Zanchi C, Burneo J, Borkowski T, Cho YJ, Ossemann M, Striano P, Srivastava K, Tan HJ, Wanigasinghe J, D’Souza W; EpiNet study group. An international pilot study of an Internet-based platform to facilitate clinical research in epilepsy: the EpiNet project. Epilepsia. 2012 Oct;53(10):1829-35.
  • Richardson MP. Large scale brain models of epilepsy: dynamics meets connectomics. J Neurol Neurosurg Psychiatry 2012;83:1238-48.
  • F1000Prime 3* (“exceptional”) recommendation http://f1000.com/prime/718120484?bd=1&ui=21503
  • O’Muircheartaigh J, Vollmar C, Barker GJ, Kumari V, Symms MR, Thompson P, Duncan JS, Koepp MJ, Richardson MP. Abnormal thalamocortical structural and functional connectivity in Juvenile Myoclonic Epilepsy. Brain 2012;135:3635-44.
  • Centeno M, Vollmar C, O’Muirchearthaigh J, Stretton J, Bonelli SB, Symms MR, Barker GJ, Kumari V, Thompson PJ, Duncan JS, Richardson MP, Koepp MJ. Memory in frontal lobe epilepsy: An fMRI study. Epilepsia 2012;53:1756-64.
  • Flores L, Kemp S, Colbeck K, Moran N, Quirk J, Ramkolea P, von Oertzen TJ, Nashef L, Richardson MP, Goulding P, Elwes R. Clinical experience with oral lacosamide as adjunctive therapy in adult patients with uncontrolled epilepsy: A multicentre study in epilepsy clinics in the United Kingdom (UK). Seizure. 2012;21:512-517.
  • Terry JR, Benjamin O, Richardson MP. Seizure generation: The role of nodes and networks. Epilepsia. 2012;53:e166-9.
  • Nicholas JM, Ridsdale L, Richardson MP, Ashworth M, Gulliford MC. Trends in antiepileptic drug utilisation in UK primary care 1993 to 2008. Cohort study using the General Practice Research Database. Seizure. 2012;21:466-470.
  • Blenkinsop A, Valentin A, Richardson MP*, Terry JR*. The dynamic evolution of focal-onset epilepsies: Combining theoretical and clinical observations. Eur J Neurosci, 2012;36:2188-2200. (* Terry and Richardson joint last authors)
  • Vollmar C, O’Muircheartaigh J, Symms MR, Baker GJ, Thompson PJ, Kumari V, Stretton J, Duncan JS, Richardson MP, Koepp MJ. Altered micro-structural connectivity in juvenile myoclonic epilepsy: The missing link. Neurology. 2012;78:1555-1559.
  • Alarcón G, Martinez J, Kerai SV, Lacruz ME, Quian Quiroga R, Selway RP, Richardson MP, Garcia Seoane JJ, Valentin A. In vivo neuronal firing patterns during human epileptiform discharges replicated by electrical stimulation. Clin Neurophysiol. 2012;123:1736-1744.
  • Benjamin O, Fitzgerald T, Ashwin P, Tsaneva-Atanasova K, Chowdhury F, Richardson MP*, Terry JR*. A phenomenological model of seizure initiation suggests network structure may explain seizure frequency in idiopathic generalised epilepsy. J Math Neurosci, 2012;2:1. (* Terry and Richardson joint last authors)
  • Nevado-Holgado AJ, Marten F, Richardson MP, Terry JR. Characterising the dynamics of EEG waveforms as the path through parameter space of a neural mass model: Application to epilepsy seizure evolution. Neuroimage. 2012;59:2374-92.
  • O’Muircheartaigh J, Richardson MP. Epilepsy and the frontal lobes. Cortex. 2012;48:144-55.
  • Richardson MP, Lopes da Silva FH. TMS studies of preictal cortical excitability change. Epilepsy Res 2011 97(3):273-7.
  • Richardson MP, Jefferys JGR. Introduction: Epilepsy Research UK Workshop 2010 on “Preictal Phenomena”. Epilepsy Res 2011 97(3):229-30.
  • Laufs H*, Richardson MP*, Salek-Haddadi A, Vollmar C, Duncan JS, Gale K, Lemieux L, Löscher W, Koepp MJ. Converging PET and fMRI evidence for a common area involved in human focal epilepsies. Neurology. 2011;77:904-10 (* Laufs and Richardson joint first authors)
  • Vollmar C, O’Muircheartaigh J, Barker GJ, Symms MR, Thompson P, Kumari V, Duncan JS, Janz D, Richardson MP, Koepp MJ. Motor system hyperconnectivity in juvenile myoclonic epilepsy: a cognitive functional magnetic resonance imaging study. Brain 2011; 134:1710-19.
  • Ridsdale L, Charlton J, Ashworth M, Richardson MP, Gulliford MC. Epilepsy mortality and risk factors for death in epilepsy: a population-based study. Br J Gen Pract 2011;61:271-8.
  • Traynor CR, Barker GJ, Crum WR, Williams SC, Richardson MP. Segmentation of the Thalamus in MRI based on T1 and T2. Neuroimage 2011;56:939-50.
  • Benjamin O, Colvin P, Kibuuka M, Alarcón G, Richardson MP, Terry JR. EEG frequency during spike-wave discharges may predict treatment outcome in patients with idiopathic generalized epilepsies. Epilepsia 2011;52:e45-8.
  • Mesquita MB, Medeiros DC, Cota RV, Richardson MP, Williams SC, Moraes MF. Distinct temporal patterns of electrical stimulation influence neural recruitment during PTZ infusion: an fMRI study. Prog Biophys Mol Biol 2011;105:109-18.
  • Richardson MP. New observations may inform seizure models: very fast and very slow oscillations. Prog Biophys Mol Biol 2011;105:5-13.
  • Vulliemoz S, Vollmar C, O’Muircheartaigh J, Yogarajah M, Carmichael DW, Stretton J, Richardson MP, Koepp MJ, Symms MR, Duncan JS. Connectivity of the supplementary motor area in juvenile myoclonic epilepsy and frontal epilepsy. Epilepsia 2011;52:507-14.
  • O’Muircheartaigh J, Vollmar C, Barker GJ, Kumari V, Symms MR, Thompson P, Duncan JS, Koepp MJ, Richardson MP. Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy. Neurology 2011;76:34–40.
  • O’Muircheartaigh J, Vollmar C, Traynor C, Barker GJ, Kumari V, Symms MR, Thompson P, Duncan JS, Koepp MJ, Richardson MP. Clustering probabilistic tractograms using independent component analysis applied to the thalamus. Neuroimage 2011;54:2020-2032
  • Osei-Lah A, Richardson MP, Alarcon G. Focal reading epilepsy – a rare variant of reading epilepsy. Epilepsia. 2010;51:2352-5.
  • Richardson MP. Update on neuroimaging in epilepsy. Expert Rev Neurother. 2010 Jun;10(6):961-73.
  • Traynor C, Heckemann RA, Hammers A, O’Muircheartaigh J, Crum WR, Barker GJ, Richardson MP. Reproducibility of thalamic segmentation based on probabilistic tractography. Neuroimage. 2010 1;52:69-85.
  • Vollmar C, O’Muircheartaigh J, Barker GJ, Symms MR, Thompson P, Kumari V, Duncan JS, Richardson MP, Koepp MJ. Identical, but not the same: intra-site and inter-site reproducibility of fractional anisotropy measures on two 3.0T scanners. Neuroimage. 2010 Jul 15;51(4):1384-94.
  • Richardson MP. Current themes in neuroimaging of epilepsy: brain networks, dynamic phenomena, and clinical relevance. Clin Neurophysiol. 2010;121:1153-75.
  • Rodrigues S, Barton D, Marten F, Kibuuka M, Alarcon G, Richardson MP, Terry JR. A method for detecting false bifurcations in dynamical systems: application to neural-field models. Biol Cybern. 2010 Feb;102(2):145-54.
  • Rotshtein P, Richardson MP, Winston JS, Kiebel SJ, Vuilleumier P, Eimer M, Driver J, Dolan RJ. Amygdala damage affects event-related potentials for fearful faces at specific time windows. Hum Brain Mapp. 2010 Jul;31(7):1089-105.
  • Rodrigues S, Barton D, Szalai R, Benjamin O, Richardson MP, Terry JR. Transitions to spike-wave oscillations and epileptic dynamics in a human cortico-thalamic mean-field model. J Comput Neurosci 2009. 27:507–526.
  • Adhikari MH, Heeroma JH, di Bernardo M, Krauskopf B, Richardson MP, Walker MC, Terry JR. Characterisation of cortical activity in response to deep brain stimulation of ventral-lateral nucleus: Modelling and experiment. J Neurosci Methods 2009; 183: 77-85.
  • Marten F, Rodrigues S, Benjamin O, Richardson MP, Terry JR. Onset of polyspike complexes in a mean-field model of human electroencephalography and its application to absence epilepsy. Philos Transact A Math Phys Eng Sci 2009; 367: 1145-61.
  • Marten F, Rodrigues S, Suffczynski P, Richardson MP, Terry JR. Derivation and analysis of an ordinary differential equation mean-field model for studying clinically recorded epilepsy dynamics. Phys Rev E Stat Nonlin Soft Matter Phys 2009; 79: 021911.
  • Salek-Haddadi A, Mayer T, Hamandi K, Symms M, Josephs O, Fluegel D, Woermann F, Richardson MP, Noppeney U, Wolf P, Koepp MJ. Imaging seizure activity: a combined EEG/EMG-fMRI study in reading epilepsy. Epilepsia 2009; 50: 256-64.
  • Powell HW, Richardson MP, Symms MR, Boulby PA, Thompson PJ, Duncan JS, Koepp MJ. Preoperative fMRI predicts memory decline following anterior temporal lobe resection. J Neurol Neurosurg Psychiatry. 2008;79:686-693.
  • Valentin A, Arunachalam R, Mesquita-Rodrigues A, Garcia-Seoane JJ, Richardson MP, Mills K, Alarcon G. Late EEG responses triggered by Transcranial Magnetic Stimulation (TMS) in the evaluation of focal epilepsy. Epilepsia. 2008;49:470-480.
  • Powell HW, Richardson MP, Symms MR, Boulby PA, Thompson PJ, Duncan JS, Koepp MJ. Reorganization of verbal and nonverbal memory in temporal lobe epilepsy due to unilateral hippocampal sclerosis. Epilepsia. 2007;48:1512-1525.
  • Wright MA, Orth M, Patsalos PN, Smith SJ, Richardson MP. Cortical excitability predicts seizures in acutely drug-reduced temporal lobe epilepsy patients. Neurology 2006;66:699-705.
  • Richardson MP, Grosse P, Allen PJ, Turner R, Brown P. BOLD correlates of EMG spectral density in cortical myoclonus: description of method and case report. Neuroimage 2006;32:558-565.
  • Richardson MP, Strange BA, Duncan JS, Dolan RJ. Memory fMRI in left hippocampal sclerosis: optimising the approach to predicting postsurgical memory. Neurology 2006;66:699-705.
  • Powell HW, Koepp MJ, Symms MR, Boulby PA, Salek-Haddadi A, Thompson PJ, Duncan JS, Richardson MP. Material specific lateralization of memory encoding in the medial temporal lobe. Neuroimage 2005;27:231-239.
  • Orth M, Kirby R, Richardson MP, Snijders AH, Rothwell JC, Trimble MR, Robertson MM, Münchau A. Subthreshold rTMS over pre-motor cortex has no effect on tics in patients with Gilles de la Tourette syndrome. Clin Neurophysiol. 2005;116:764-8.
  • Vuilleumier P, Richardson MP, Armony JL, Driver J, Dolan RJ. Distant nfluences of amygdala on visual cortex activation during emotional face processing. Nature Neuroscience 2004; 7:1271-1278.
  • Richardson MP, Strange BA, Thompson PJ, Baxendale SA, Duncan JS, Dolan RJ. Preoperative verbal memory fMRI predicts postoperative memory decline after left temporal lobe resection. Brain 2004;127:2419-26.
  • Powell HW, Koepp MJ, Richardson MP, Symms MR, Thompson PJ, Duncan JS. The application of functional MRI of memory in temporal lobe epilepsy: a clinical review. Epilepsia 2004; 45: 855-863.
  • Richardson MP, Strange BA, Dolan RJ. Encoding of emotional memories depends on amygdala and hippocampus and their interactions. Nature Neuroscience 2004; 7: 278-285.
  • Richardson MP, Strange BA, Duncan JS, Dolan RJ. Preserved verbal memory function in left medial temporal pathology involves reorganisation of function to right medial temporal lobe. Neuroimage 2003; 20: S112-9.
  • Baxendale S, Thompson P, Duncan J, Richardson M. Is it time to replace the Wada test? Neurology 2003; 60: 354-355.
  • Vincent TL, Richardson MP, Mackworth-Young CG, Hawke SH, Venables PJW. Sjogren’s syndrome associated myelopathy: response to immunosuppressive treatment. Am J Med 2003; 114: 145-148.
  • Hammers A, Koepp MJ, Richardson MP, Hurlemann R, Brooks DJ, Duncan JS. Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI. A PET study of 44 patients. Brain 2003; 126: 1300-1318.
  • Richardson MP. Epilepsy and surgical mapping. British Medical Bulletin 2003;65:179-192.
  • Bartlett PA, Richardson MP, Duncan JS. Measurement of amygdala T2 relaxation time in temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 2002;73:753-5.
  • Hammers A, Koepp MJ, Hurlemann R, Thom M, Richardson MP, Brooks DJ, Duncan JS. Abnormalities of grey and white matter [(11)C]flumazenil binding in temporal lobe epilepsy with normal MRI. Brain 2002;125:2257-2271.
  • Hammers A, Koepp MJ, Free SL, Brett M, Richardson MP, Labbe C, Cunningham VJ, Brooks DJ, Duncan JS. Implementation and application of a brain template for multiple volumes of interest. Hum Brain Mapp 2002;15(3):165-174.
  • Richardson MP. Case reports – functional imaging in epilepsy. Seizure 2001;10:157-161.
  • Richardson MP. Functional imaging in epilepsy. Seizure 2001; 10: 139-56.
  • Richardson MP, Hammers A, Brooks DJ, Duncan JS. Benzodiazepine-GABAA receptor binding is very low in dysembryoplastic neuroepithelial tumour: a PET study. Epilepsia 2001; 42: 1327-34.
  • Hammers A, Koepp MJ, Richardson MP, Labbe C, Brooks DJ, Cunningham VJ, Duncan JS. Central benzodiazepine receptors in malformations of cortical development: A quantitative study. Brain 2001; 124: 1555-65.
  • Lloyd CM, Richardson MP, Brooks DJ, Al-Chalabi A, Leigh PN. Extramotor involvement in ALS: PET studies with the GABAA ligand 11C-flumazenil. Brain 2000;123:2289-2296.
  • Capaday C, Richardson MP, Rothwell J, Brooks DJ. Long-term changes of GABAergic function in the sensorimotor cortex of amputees: A combined magnetic stimulation and 11C-flumazenil PET study. Exp Brain Res 2000;133:552-556.
  • Jalan R, Turjanski N, Taylor-Robinson SD, Koepp MJ, Richardson MP, Wilson JA, Bell JD, Brooks DJ. Increased availability of central benzodiazepine receptors in patients with chronic hepatic encehalopathy and alcohol-related cirrhosis. Gut 2000;46:546-552.
  • Koutroumanidis M, Koepp MJ, Richardson MP, Camfield C, Agathonikou A, Ried S, Papadimitriou A, Plant GT, Duncan JS, Panayiotopoulos CP. The variants of reading epilepsy. A clinical and video-EEG study of 17 patients with reading-induced seizures. Brain 1998;121:1409-27.
  • Koepp MJ, Richardson MP, Brooks DJ, Duncan JS. Focal cortical release of endogenous opioids during reading-induced seizures. Lancet 1998;352:952-5.
  • Richardson MP, Koepp MJ, Brooks DJ, Coull J, Grasby P, Fish DR, Duncan JS. Cerebral activation in malformations of cortical development. Brain 1998;121:1295-304.
  • Richardson MP, Koepp MJ, Brooks DJ, Duncan JS. 11C-flumazenil PET in neocortical epilepsy. Neurology 1998;51:485-92.
  • Koepp MJ, Hand KSP, Labbe C, Richardson MP, Van Paesschen W, Baird VH, Cunningham VJ, Bowery NG, Brooks DJ, Duncan JS. In-vivo 11C-flumazenil PET correlates with ex-vivo 3H-flumazenil autoradiography in hippocampal sclerosis. Ann Neurol 1998;43:618-26.
  • Koepp MJ, Richardson MP, Labbe C, Brooks DJ, Cunningham VJ, Ashburner J, Van Paesschen W, Revesz T, Duncan JS. C-11-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy. Neurology 1997;49:764-73.
  • Koepp MJ, Richardson MP, Brooks DJ, Cunningham VJ, Duncan JS. Central benzodiazepine/gamma-aminobutyric acid(A) receptors in idiopathic generalized epilepsy: An [C-11]flumazenil positron emission tomography study. Epilepsia 1997;38:1089-97.
  • Koepp MJ, Labbé C, Richardson MP, Brooks DJ, Van Paesschen W, Cunningham VJ, Duncan JS. Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis. Brain 1997;120:1865-76.
  • Richardson MP, Friston KJ, Sisodiya SM, Koepp MJ, Ashburner J, Free SL, Brooks DJ, Duncan JS. Cortical grey matter and benzodiazepine receptors in malformations of cortical development: a voxel-based comparison of structural and functional imaging data. Brain 1997;120:1961-73.
  • Koepp MJ, Richardson MP, Brooks DJ, Poline JB, Friston KJ, Cunningham VJ, Duncan JS. Cerebral benzodiazepine receptors in hippocampal sclerosis: an objective in vivo analysis. Brain 1996;119:1677-87.
  • Richardson MP, Koepp MJ, Fish DR, Brooks DJ, Duncan JS. Benzodiazepine receptors in focal epilepsy with cortical dysgenesis: an 11C-flumazenil PET study. Ann Neurol 1996;40:188-98.
  • Richardson MP, Lever AML. Neisserial disease. J Infection 1996;32:175-176.
  • Richardson MP, Lever AML, Fink AM, Dixon AK, Hazelman BL. Survival after aortic dissection in giant-cell arteritis. Ann Rheumatic Dis 1996;55:332-333.
  •  Malizia AL, Richardson MP. Benzodiazepine receptors and positron emission tomography: ten years of experience. A new beginning? J Psychopharmacol 1995;9:335-68.
  • Richardson MP, Thuraisingham SI, Dunning J. Apparent superior vena cava obstruction and a continuous murmur : an unusual complication of aortocoronary saphenous vein grafts. Br Heart J 1992;68:412-3
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