Simon S. Keller

King’s College London

Dr. Keller leads neuroimaging applications in the Epilepsy Research Group (ERG) at the University of Liverpool, in close collaboration with the Walton Centre NHS Foundation Trust (www.thewaltoncentre.nhs.uk). Research within the ERP covers a broad spectrum, from basic laboratory investigations to patient-focused projects, and addresses some of the most significant issues in epilepsy therapeutics.

Dr. Keller’s research interest is the use of advanced quantitative neuroimaging techniques, mainly MRI, to determine the prognosis of people with neurological disorders after medicinal or surgical intervention, particularly in people with epilepsy.

Previous Postdoctoral Experience:

  • MARIARC, University of Liverpool (2005-2009): Research Associate.
  • Department of Neurology, University of Muenster, Germany (2009-2011): Research Associate
  • Department of Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London (2012-2013): Lecturer
  • Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool (2013-): Lecturer and Principle Investigator

Qualifications:

  • PhD (Neuroimaging in Epilepsy)
  • MSc (Cognitive Neuroscience)
  • BSc Hons (Psychology)

Core expertise:

  • Quantitative neuroimaging
  • Neurology
  • Neuroscience

Publications and Posters:

  • Paper: Keller, S. S., Richardson, M. P., O’Muircheartaigh, J., Schöne-Bake, J-C., Elger, C., Weber, B. 2015. Morphometric MRI alterations and postoperative seizure control in refractory temporal lobe epilepsy. Human Brain Mapping, in press.
  •  Paper: Wieshmann, U.C., Milinis, K., Paniker, J., Crooks, D., Das, K., Jenkinson, M., Brodbelt, A., Keller, S. S. 2015. The role of the corpus callosum in seizure spread: MRI lesion mapping in oligodendrogliomas. Epilepsy Research, in press.
  •  Paper: Keller, S. S., O’Muircheartaigh, J., Traynor, C., Towgood, K., Barker, G. J., Richardson, M. P. 2014. Thalamotemporal impairment in temporal lobe epilepsy: A combined MRI analysis of structure, integrity and connectivity. Epilepsia, 55(2):306-15.
  •  Paper: Schöne-Bake, J-C.,§ Keller, S. S.,§ Niehusmann, P., Volmering, E., Elger, C., Deppe, M., Weber, B. 2014. In-vivo mapping of hippocampal subfields in mesial temporal lobe epilepsy: relation to histopathology. Human Brain Mapping, 35(9):4718-28. §Denotes shared first authorship.
  •  Paper: Keller, S. S., Ahrens, T., Mohammadi, S., Gerdes, J. S., Möddel, G., Kellinghaus, K., Kugel, H., Ringelstein, E., Deppe, M. 2013. Voxel-based statistical analysis of fractional anisotropy and mean diffusivity in patients with unilateral temporal lobe epilepsy of unknown cause. J Neuroimaging, 10(4):341-50.
  •  Paper: Keller, S. S., Schöne-Bake, J-C., Gerdes, J. S., Weber, B., Deppe, M. 2012. Concomitant fractional anisotropy and volumetric brain abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury. PLoS One, 7(10):e46791.
  •  Paper: Gerdes, S., Keller, S. S., Evers, S., Schwindt, W., Walther, E., Deppe, M. 2012. Progression of putamen diffusion alterations in a case of symptomatic recurrent seizures using diffusion tensor imaging. Seizure, 21(6):478-81.
  •  Paper: Keller, S. S., Gerdes, J. S., Mohammadi, S., Kellinghaus, C., Kugel, H., Deppe, K., Ringelstein, E., Evers, S., Schwindt, W., Deppe, M. 2012. Volume estimation of the thalamus using FreeSurfer and Stereology on MR images: consistency between methods. Neuroinformatics 10:341-350.
  •  Paper: Keller, S. S., Ahrens, T., Mohammadi, S., Möddel, G., Kugel, H., Ringelstein, E., Deppe, M. 2011. Microstructural and volumetric abnormalities of the putamen in Juvenile Myoclonic Epilepsy. Epilepsia, 52(9): 1715-1724.
  •  Paper: Keller, S. S., Roberts, N., Garcia-Finana, M., Mohammadi, S., Ringelstein, E., Knecht, S., Deppe, M. 2011. Can the language dominant hemisphere be predicted by brain anatomy? J Cog Neurosci 23:2013-2029.