We are delighted to invite you to join us for BioDynamics 2018 at the beautifully located Royal College of Physicians, Regents Park, London.

Dynamic phenomena are ubiquitous in biological systems and span multiple, interacting spatiotemporal scales. There is growing appreciation that quantifying them accurately will lead to deeper insights into human disease and even inspire novel therapies – but doing so is challenging, and will likely need innovative cross-disciplinary approaches and tools.

BioDynamics 2018 will showcase some of the very best cross-disciplinary research in this rapidly expanding field, with a focus on how the study of biological dynamics, and the mechanistic understanding it provides, can be used for clinical translation and patient-specific therapeutics. Talks will range from microscopic scales – how molecular dynamics influence disease phenotypes – to macroscopic scales – how neural, humoral and cardiovascular dynamics affect human health and disease.

This year the meeting will be organised by colleagues from King’s College London and will be held on the 12th & 13th April 2018 at the Royal College of Physicians. This wonderful venue is in the heart of London, overlooking Regent’s park.

Biodynamics 2018 Organising Committee:

  • Mark Richardson
  • Zoran Cvetkovic
  • Franca Fraternali
  • Kevin O’Byrne
  • Steven Niederer
  • Ivana Rosenzweig

Registration

If you would like to register for this years’ meeting please click on the ‘register’ tab below to visit King’s College London’s secure registration and payment pages. A number of abstracts will be accepted for short highlighted orals, and you should indicate when registering if you wish your poster to be so considered. Registration fees are as follows:

  • Early Bird Registration* (Lecturer and above) – £200
  • Early Bird Registration* (PhD and PostDoc) – £150
  • Full Registration (Lecturer and above) – £250
  • Full Registration (PhD and PostDoc) – £200

REGISTER

* Please note that Early bird deadline is 1st March 2018.

Overview of themes covered

Theme 1 “Motor Neuroscience”

Chair: Professor Zoran Cvetkovic

Unravelling mechanisms of movement control and how they are disrupted in individuals with movement disorders requires holistic interdisciplinary approaches. This session represents an overview of the field and recent research advances in computational motor control, motor neurophysiology, brain networks and clinical neurophysiology, aiming to spur some new synergies in this very complex and exciting field.

Theme 2 “Molecular Mechanisms and Modelling of Diseases”

Chair: Professor Franca Fraternali

Progresses in Translational Medicine will have to proceed hand-in-hand with the discovery of the molecular mechanisms underlying the cell pathological states. Dissecting these, together with the introduction of molecular diagnostics into medical practice, will result essential in the annotation of disease pathogenesis and in the design of tailored and effective patient treatments.

This workshop will be dedicated to highlight some of the recent discoveries of molecular mechanisms playing a role in neurodegenerative disorders and cancer. We will highlight the importance of biophysical, analytical and computational tools in assessing and quantifying these mechanisms.

Theme 3 “Neural Oscillations in Health and Disease”

Chair: Dr Ivana Rosenzweig

The emerging field of neuronal oscillations provides an exciting interdisciplinary platform that cuts across physics, neuroscience, neuromodulation, sleep medicine, psychology, biophysics, computational modelling and mathematics. Mammalian cortical neurons form oscillating networks of various sizes, and resulting neural oscillations are known to be phylogenetically preserved, and likely functionally relevant. This session will provide an overview of the recent research advances in understanding their physiological mechanisms and functions, as well as highlight some possible ground-breaking possibilities, which neuromodulation might provide for the diagnosis and treatment of brain disorders.

Theme 4 “Stress and the Brain”

Chair: Professor Kevin O’Byrne

Although circadian rhythms of hormones and changes across the reproductive cycle have been known for many years, the measurement of a single hormone level is still frequently considered sufficient for clinical diagnosis or as a measure of the physiological state of an experimental animal. We have used the hypothalamo-pituitary-adrenal axis as a model system to examine the dynamical systems involved in co-ordinating multiple internal and external stimuli and the subsequent provision of an appropriate dynamic output. I will describe how systems levels generation of oscillating glucocorticoids interact with regulatory systems within individual units of the axis and how this results in a pulsatile output signal that needs decoding in a tissue specific manner at cellular level. I will describe how this changes during clinically stressful situations and also how disruption of the oscillating signal with synthetic glucocorticoids disrupts many physiological systems.

Theme 5 “Patient Specific Modelling”

Chair: Dr Steven Niederer

Computational models provide a mathematical framework for integrating data from an individual patient and interpreting it within the context of known physical laws and physiology. Patient specific models can then be used to analyse an individual patient to identify the mechanisms underpinning their pathology, to provide inferred measurements such as muscle stress or work, or to predict how a patient will respond to a therapy. This session will provide a broad review exemplar applications of computational modelling across the fields of muscle-skeletal, cardiac, cardiovascular and drug delivery.

Abstracts

The local organisers invite you to submit abstracts for poster presentations, which will be displayed prominently during the conference. A number of abstracts will be accepted for short highlighted orals, and you should indicate when registering if you wish your poster to be so considered.

  • Abstracts must be no longer than 250 words and emailed to: amber.collingwood@kcl.ac.uk.
  • Please indicate in your email your full name, position, university and whether you wish to be considered for a short highlighted oral presentation.
  • If you do not wish to be considered, please state this clearly. Please ensure your abstract is submitted in an MS office word document with your details clearly stated in the header/footer. Abstract deadline Monday 12th February 2018 at 4pm.

You will be contacted by email approximately one month before the meeting letting you know whether you have been chosen to present a poster and/or give a short highlighted oral.

Venue information


Located in central London overlooking Regent’s Park, The Royal College of Physicians (RCP) is an award-winning and highly versatile venue that will host the Biodynamics 2018 Conference.

11 St Andrews Pl
Regent’s Park
London NW1 4LE

Accommodation information

Meeting organiser contact information

Amber Collingwood

amber.collingwood@kcl.ac.uk

0207 848 5162