Isabella Premoli

Isabella obtained her combined BA and MD in Pharmacy from the University of Pavia, Italy. She completed the experimental part of her MD thesis at the Faculty of Pharmacy of the University of Sydney, Australia, where she worked on the electrophysiological evaluation of flavonoids as new possible anxiolytic agents.

Following this experience, Isabella pursued a Ph.D. in Behavioral Neuroscience at the University Hospital of Tübingen in collaboration with the International Max Planck Research School.

Her PhD focused on the investigation of GABAergic neurotransmission by combining TMS and EEG under pharmacological challenge. TMS-EEG is a relatively novel tool which can assess brain excitability and connectivity. By using drugs with a well-known mode of action we defined markers for GABA-A and GABA-B receptor mediated neurotransmission in the healthy human brain.

Qualifications:

• BA and MD in Medicinal Chemistry and Pharmaceutical Technologies, Faculty of Pharmacy of The University of Pavia, Italy.
• PhD in Behavioural Neuroscience at the Max Planck International Research School of Tübingen, Germany.

Core expertise:

• TMS
• EEG
• TMS-EEG
• Pharmacology

Publications and Posters:

• Paper: Premoli I., Rivolta D., Espenhahn S., Belardinelli P., Castellanos N., Müller-Dahlhaus F. & Ziemann, U. (2014). Characterization of GABAB-receptor mediated neurotransmission in the human cortex by paired-pulse TMS-EEG. Neuroimage (in press).
• Paper: Premoli, I., Castellanos N., Rivolta D., Belardinelli P., Bajo R., Zipser C., Espenhahn S., Heidegger T., Müller-Dahlhaus F. & Ziemann, U. (2014). TMS-EEG signatures of GABAergic neurotransmission in the human cortex. Journal of Neuroscience 34(16), 5603-5612.
• Paper: Chebib, M., Gavande, N., Wong, K.Y., Park, A., Premoli, I., Mewett, K.N., Allan, R.D., Duke, R.K., Johnston, G.A.R., & Hanrahan, J.R. (2009). Guanidino acids act as rho1 GABA C receptor antagonists. Neurochemical Research, 34(10), 1704-1711.