Andrea Biondi

Postdoctoral Researcher, King’s College London

Andrea is a neuroscientist and psychologist with a strong interest in wearable technology, digital health, psychophysiology, and neuroscience. Currently, he works as a research associate on the IMPARTS project at King’s College London, under the supervision of Prof Mark Richardson and Prof Deb Pal. This project aims to bridge the gap between mental and physical health care in epilepsy management within Kings Health Partners.

Previously, during his PhD in Clinical Neuroscience, Andrea led the EEG@HOME project. This initiative aimed to develop a safe and independent procedure for epilepsy patients to collect daily EEG data at home using a wearable EEG cap, alongside continuous data from smartwatches and smartphone apps. Ultimately, Andrea aims to construct a model based on these datasets to identify periods of heightened seizure risk, contributing to the advancement of remote monitoring and management of epilepsy patients in digital health.

His primary focuses now lies within the integration of digital mental health interventions in epilepsy care and the development of new digital solutions to monitor physiological and behavioural variables and manage symptoms remotely.

Previous experience:

  • Oct 2019 – March 2023. Andrea worked as a PhD student in Clinical Neuroscience leading the EEG@HOME project. The main aim was to develop a procedure that would allow patients with epilepsy to independently and safely collect daily at-home EEG and continuous data from smartwatches and smartphone apps.
  • Sep 2017 – Sep 2019. Andrea worked as a research assistant on the RADAR epilepsy work package. This is one of eleven work packages in the Remote Assessment of Disease and Relapse in Central Nervous System Disorders (RADAR-CNS) Project. Andrea closely supervises the collection of clinical information and data from wearable devices (ECG, GSR, EMG, ACC), clinical EEGs, questionnaires, and interviews with patients in the hospital EEG monitoring unit.
  • Feb 2017 – Jul 2017.  Andrea was a volunteer at Ancona (Italy) one of the most valued Hospital for geriatric and neurological diseases (I.N.R.C.A.). He evaluated patients with different kinds of dementia (Fronto-Temporal, Alzheimer or Dysexecutive) using standardised neuropsychological tests.
  • Nov 2015 – Nov 2016.  During his one-year apprenticeship, he worked for six months at the Besta Hospital in Milan while he improved his neuropsychological skills and six months at the King’s College of London using TMS and EEG to record TMS-evoked-potential and he learnt how to use Fieldtrip and others software for the analysis of TMS-EEG data.
  • Sept 2014 – Sep 2015. During his master’s degree, he spent one year as a neuropsychologist trainee at the Lex-Mea Lab (Padua University) and in the Department of Neuroscience and Psychiatry at Padua Hospital for collecting behavioural and electrophysiological data using neuropsychological questionnaires and EEG.

Qualifications:

  • 1st October 2023 – Awarded as a Doctor of Philosophy in Clinical Neuroscience.
  • 20th Oct 2017 – Registered in the “Register of Italian Psychologists” after “State Examination”. N: 2820
  • 2013 – 2015 – Master’s Degree in Neuroscience and Neuropsychological Rehabilitation (Summa Cum Laude – Distinction)
  • 2010 – 2013 – Bachelor’s Degree in Cognitive Psychology and Psychobiology

Core expertise:

  • EEG, EEG-TMS & EEG-fMRI data acquisition;
  • EEG data analysis;
  • Semi-structured Interview and qualitative data analysis;
  • Systematic Review of the literature;
  • Research ethics and governance;
  • Patient and public involvement (PPI);
  • Neuropsychological/Psychological and Cognitive Assessment.

Speciality:

  • Neuroscience;
  • Remote monitoring;
  • Digital Health;
  • Wearable Technology;
  • Clinical Neuropsychology.

Profile Links:

https://www.researchgate.net/profile/Andrea-Biondi-5

https://www.linkedin.com/in/andrea-biondi-phd-916452185/

https://epilepsy-london.org/doctor/andrea-biondi/

Publications:

  1. Biondi, A., Simblett, S. K., Viana, P. F., Laiou, P., Fiori, A. M., Nurse, E., … & Richardson, M. P. (2024). Feasibility and acceptability of an ultra-long-term at-home EEG monitoring system (EEG@ HOME) for people with epilepsy. Epilepsy & Behavior, 151, 109609.
  2. Laiou, P., Biondi, A., Bruno, E., Viana, P. F., Winston, J. S., Rashid, Z., … & Radar-Cns Consortium. (2022). Temporal evolution of multiday, epileptic functional networks prior to seizure occurrence. Biomedicines, 10(10), 2662.
  3. Böttcher, S., Vieluf, S., Bruno, E., Joseph, B., Epitashvili, N., Biondi, A., … & Loddenkemper, T. (2022). Data quality evaluation in wearable monitoring. Scientific reports, 12(1), 21412.
  4. Biondi, A., Santoro, V., Viana, P. F., Laiou, P., Pal, D. K., Bruno, E., & Richardson, M. P. (2022). Noninvasive mobile EEG as a tool for seizure monitoring and management: A systematic review. Epilepsia, 63(5), 1041-1063.
  5. Viana, P. F., Pal Attia, T., Nasseri, M., Duun‐Henriksen, J., Biondi, A., Winston, J. S., … & Brinkmann, B. H. (2022). Seizure forecasting using minimally invasive, ultra‐long‐term subcutaneous electroencephalography: Individualized intrapatient models. Epilepsia.
  6. Viana, P. F., Nasseri, M., Duun-Henriksen, J., Biondi, A., Winston, J. S., Martins, P., … & Richardson, M. P. (2022). Seizure forecasting using minimally invasive, ultra-long-term subcutaneous EEG: Generalizable cross-patient models. Epilepsia.
  7. Di Hou, M., Santoro, V., Biondi, A., Shergill, S. S., & Premoli, I. (2021). A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia. Journal of Psychiatry and Neuroscience, 46(6), E675-E701.
  8. Biondi, A., Rocchi, L., Santoro, V., Rossini, P. G., Beatch, G. N., Richardson, M. P., & Premoli, I. (2022). Spontaneous and TMS-related EEG changes as new biomarkers to measure anti-epileptic drug effects. Scientific reports, 12(1), 1-11.
  9. Elisa Bruno, Sebastian Böttcher, Pedro F. Viana, Marta Amengual-Gual, Boney Joseph, Nino Epitashvili, Matthias Dümpelmann, Martin Glasstetter, Andrea Biondi, Kristof Van Laerhoven, Tobias Loddenkemper, Mark P. Richardson, Andreas Schulze-Bonhage, Benjamin H. Brinkmann (2021). Wearable devices for seizure detection: Practical experiences and recommendations from the Wearables for Epilepsy And Research (WEAR) International Study Group. Epilepsia, https://doi.org/10.1111/epi.17044.
  10. Biondi, A., Laiou, P., Bruno, E., Viana, P. F., Schreuder, M., Hart, W., … & Richardson, M. P. (2021). Remote and long-term self-monitoring of electroencephalographic and noninvasive measurable variables at home in patients with epilepsy (EEG@ HOME): protocol for an observational study. JMIR research protocols, 10(3), e25309.
  11. Bruno, E., Biondi, A., Richardson, M. P., & Radar-Cns Consortium. (2021). Digital semiology and time-evolution pattern of bio-signals in focal onset motor seizures. Seizure, 87, 114-120.
  12. Bruno, E., Biondi, A., Böttcher, S., Lees, S., Schulze-Bonhage, A., Richardson, M. P., & RADAR-CNS Consortium. (2020). Day and night comfort and stability on the body of four wearable devices for seizure detection: A direct user-experience. Epilepsy & Behavior, 112, 107478.
  13. Bruno, E., Biondi, A., Böttcher, S., Vértes, G., Dobson, R., Folarin, A., … & Richardson, M. (2020). Remote Assessment of Disease and Relapse in Epilepsy: Protocol for a Multicenter Prospective Cohort Study. JMIR research protocols, 9(12), e21840.
  14. Bruno, E., Biondi, A., Thorpe, S., Richardson, M. P., & RADAR-CNS Consortium. (2020). Patients self-mastery of wearable devices for seizure detection: a direct user-experience. Seizure, 81, 236-240.
  15. Nasseri, M., Nurse, E., Glasstetter, M., Böttcher, S., Gregg, N. M., Laks Nandakumar, A., Boney J., Tal Pal A., Viana P.F., Bruno E., Biondi A., Cook M., Worrell G.A., Schulze‐Bonhage A., Dümpelmann M., Freestone D.R., Richardson M.P. & Brinkmann, B. H. (2020). Signal quality and patient experience with wearable devices for epilepsy management. Epilepsia.
  16. Bruno, E., Böttcher, S., Biondi, A., Epitashvili, N., Manyakov, N. V., Lees, S., … & RADAR-CNS Consortium. (2020). Post‐ictal accelerometer silence as a marker of post‐ictal immobility. Epilepsia, 61(7), 1397-1405.
  17. Shek, A. C., Biondi, A., Ballard, D., Wykes, T., & Simblett, S. K. (2021). Technology-based interventions for mental health support after stroke: A systematic review of their acceptability and feasibility. Neuropsychological rehabilitation, 31(3), 432-452.
  18. Simblett, S. K., Biondi, A., Bruno, E., Ballard, D., Stoneman, A., Lees, S., … & Wykes, T. (2020). Patients’ experience of wearing multimodal sensor devices intended to detect epileptic seizures: a qualitative analysis. Epilepsy & Behavior, 102, 106717.
  19. Simblett, S. K., Bruno, E., Siddi, S., Matcham, F., Giuliano, L., López, J. H., Biondi, A. … & Zappia, M. (2019). Patient perspectives on the acceptability of mHealth technology for remote measurement and management of epilepsy: A qualitative analysis. Epilepsy & Behavior, 97, 123-129.
  20. Bruno, E., Maira, G., Biondi, A., Richardson, M. P., & RADAR-CNS Consortium. (2018). Ictal hypoxemia: A systematic review and meta-analysis. Seizure, 63, 7-13.
  21. Bruno, E., Simblett, S., Lang, A., Biondi, A., Odoi, C., Schulze-Bonhage, A., … & RADAR-CNS Consortium. (2018). Wearable technology in epilepsy: The views of patients, caregivers, and healthcare professionals. Epilepsy & Behavior, 85, 141-149.
  22. Bruno, E., Biondi, A., & Richardson, M. P. (2018). Pre-ictal heart rate changes: A systematic review and meta-analysis. Seizure-European Journal of Epilepsy, 55, 48-56.
  23. Premoli, I., Bergmann, T. O., Fecchio, M., Rosanova, M., Biondi, A., Belardinelli, P., & Ziemann, U. (2017). The impact of GABAergic drugs on TMS-induced brain oscillations in human motor cortex. Neuroimage, 163, 1-12.
  24. Premoli, I., Biondi, A., Carlesso, S., Rivolta, D., & Richardson, M. P. (2017). Lamotrigine and levetiracetam exert a similar modulation of TMS‐evoked EEG potentials. Epilepsia, 58(1), 42-50.
  25. Premoli, I., Costantini, A., Rivolta, D., Biondi, A., & Richardson, M. P. (2017). The effect of lamotrigine and levetiracetam on TMS-evoked EEG responses depends on stimulation intensity. Frontiers in Neuroscience, 11, 585.

Conference Presentation and Posters:

    1. Biondi A., Laiou P., Schreuder M., Viana F.P., Richardson M.P. EEG@HOME: seizure cycles and temporal patterns in long-term at-home e-diary, smartwatch, and mobile EEG data, in a drug-resistant epilepsy patient. Fourth International Congress on Mobile Health and Digital Technology (Lausanne, 2023).
    2. Biondi A., Laiou P., Anthony V., Pal D., Richardson M.P. EEG graph theory biomarkers for epilepsy diagnosis in children with SeLECTS. 35th International Epilepsy Congress (Dublin, Online, 2023)
    3. Biondi A., Laiou P., Bruno E., Viana F.P., Winston J.S., Richardson P.M., and the RADAR CNS Consortium. Multiday brain network features computed from interictal EEG recordings suggest topological changes before the seizure occurrence. ICTALS 2022 Conference (Bern, 2022)
    4. Biondi A., Viana P.F., Schreuder M., Pal D., Richardson M.P. Feasibility and acceptability of a 6‐months remote, at‐home procedure to monitor and collect EEG and non‐EEG biosignals in people with epilepsy (EEG@HOME). a first case report. American Epilepsy Society (AES) 2021 Meeting (Online, 2021).
    5. Biondi A., Schreuder M., Laiou P., Pal D., Richardson M.P. The acceptability of a remote, at home, long‐term procedure to monitor EEG and non‐EEG biosignals in people with epilepsy (EEG@HOME). In 34th International Epilepsy Congress (Online 2021).
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